
学历/学位:研究生/博士
人才项目:国家自然科学基金 杰青、优青;科协青托
ytf0707@126.com.
所在单位及职务
上海交通大学心理学院 特聘教授、执行院长
上海交通大学医学院附属精神卫生中心 教授、研究员
国家精神疾病医学中心脑健康研究院 执行院长
教育经历
博士——日内瓦大学(2013) 导师: Christian Luscher教授
硕士——香港大学(2009) 导师: 苏国辉院士
本科——中山大学(2007)
工作经历
上海交通大学心理学院(2024.7-今) 特聘教授
上海交通大学医学院附属精神卫生中心(2017.7-今) 教授,博导
南京师范大学心理学院(2013.9-2017.6) 教授,博导
学术兼职
香港大学脑与认知科学国家重点实验室 荣誉副教授
中国神经科学学会——青年工作委员会 副主任委员
中国神经科学学会——应激神经生物学分会 副主任委员、秘书长
中国康复医学会——脑功能检测与调控康复专业委员会 副主任委员
中国认知科学学会——认知与脑调控分会 副主任委员、秘书长
中国毒理学会——药物依赖性毒理学专业委员会 副主任委员
中国研究型医院学会——神经再生与修复专业委员会 副主任委员
亚洲药物滥用研究学会——成瘾心理治疗专委会 副主任委员
司法部戒毒管理局——司法行政戒毒工作专家咨询委员会 委员
上海市神经科学学会——青年创新工作委员会 主任委员
学术期刊编委
Frontiers in Psychiatry (Specialty Chief Editor for Neurostimulation) IF=4.7
Stress and Brain (Associate Editor in Chief)
Brain, Behavior, and Immunity (Board Member) IF=15.1
Scientific Data (Board Member) IF=9.8
Pharmacological Research (Guest Associate Editor) IF=9.3
主要研究方向
l 药物成瘾的神经机制研究
l 脑疾病与脑可塑性研究
l 神经调控技术干预皮层可塑性研究
主要荣誉
欧盟玛丽.居里基金ITN fellowship (2010-2013)
欧盟 EMBO Short term fellowship (2015)
江苏医学科学奖二等奖(2015,R4)
英国牛顿 Newton Mobility Award (2016)
江苏省"青蓝工程"中青年学术带头人(2016)
中国科协青年人才托举工程(心理学会首批入选)(2017)
上海市青年科技启明星 (2018)
上海市卫生计生系统学术带头人(2018)
国家“优青”(2018)
中华医学科技奖三等奖(2020,R2)
上海医学科技奖一等奖(2019,R2)
上海市卫生系统银蛇奖(2021,提名)
上海医学科技奖青年奖(2021,R1)
华夏医学科技奖三等奖(2022,R2)
上海市科委学术带头人(2023)
国家“杰青”(2023)
中华医学科技奖二等奖(2024,R3)
部分主持项目
1. 主持,国家重点研发计划生物大分子与微生物组,2024YFA1306900,抑郁障碍的肠-脑整合机制研究,2025/01-2030/12,2414 万元,在研
2. 主持,国家自然科学基金国际(地区)合作与交流项目- NSFC-FDCT(内地-澳门),82461160261,Rac1-DIAPH3通过相分离调控脑刺激成瘾干预后伏隔核突触重塑的机制研究,2025/01-2027/12,170万元,在研
3. 主持,上海交通大学2030项目(B类),情绪的化学合成生物学研究,2025/01-2027/12,500万元,在研
4. 主持,国家自然科学基金杰出青年科学基金,82325019,成瘾的神经机制与干预研究,2024/01-2028/12,400万元,在研;
5. 主持,国家自然科学基金专项经费,32241015,运动干预甲基苯丙胺成瘾的整合生理学与神经机制研究,2023/01-2025/12,63万元,在研;
6. 主持,科技部干细胞专项,通过三维导电生物材料和电刺激调控神经干细胞构建体外类脑与内耳器官的研究(2020YFA0113600),青年科学家项目,2020/10-2024/12,541万元,结题;
7. 主持,国家自然科学基金优秀青年科学基金,81822017,药物成瘾,2019/01-2021/12,130万元,结题;
8. 主持,国家自然科学基金面上项目,31771215,甲基苯丙胺成瘾者冲动行为及经颅磁刺激干预研究,2018/01-2021/12,60万元,结题;
部分代表性论文
(* 表示通讯作者, #表示共同第一作者)
1. Li J #, Jiang Y #, Cheng D, Cheng J, Hu J *, Wang X *, Yuan TF * (2025) Psychedelics for treating psychiatric disorders: From circuit mechanisms to applications. Sci Bull (Beijing). S2095-9273(24)00849-1; in press
2. Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S *, Chen X *, Yuan TF *, Zhu S * (2024) Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. Nat Struct Mol Biol 31(12):1987-1996.
3. Lin ZJ, Gu X, Gong WK, Wang M, Wu YJ, Wang Q, Wu XR, Zhao XY, Zhu MX, Wang LY, Liu Q, Yuan TF*, Li WG*, Xu TL* (2024) Stimulation of an entorhinal-hippocampal extinction circuit facilitates fear extinction in a post-traumatic stress disorder model. J Clin Invest 134(22):e181095.
4. Zheng H #, Zhai T #, Lin X, Dong G, Yang *, Yuan TF * (2024) The resting-state brain activity signatures for addictive disorders. Med 5: 201-223.
5. Tian W #, Zhao D #, Ding J, Zhan S, Zhang Y, Etkin A, Wu W *, Yuan TF * (2024) An electroencephalographic signature predicts craving for methamphetamine. Cell Rep Med 5: 10134.
6. Liu QM #, Lucas M #, Badami F, Wu W *, Etkin A, Yuan TF * (2024) Cortical plasticity differences in substance use disorders. Fundamental Research 4: 1351-1356.
7. Xu Y, Zhang Y, Zhao D, Tian Y *, Yuan TF * (2023) Growing placebo response in Transcranial Magnetic Stimulation treatment for depression: A meta-analysis of twenty-seven-year randomized sham-controlled trials. Nature Mental Health, 1: 792–809.
8. Fu Y #, Yang Y #, Huang L #, Huang X, Yang Q, Tao Q, Wu J, So KF, Lin S *, Yuan TF *, Ren C * (2023) A visual circuit related to the habenula mediates the prevention of cocaine relapse by bright light treatment. Sci Bull (Beijing). 68(18):2063-2076.
9. Zhu XN #, Li J #, Qiu GL #, Wang L, Lu C, Guo YG, Yang KX, Cai F, Xu T *, Yuan TF *, Hu J * (2023) Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter, Neuron, 111: 1626-36.
10. Zhang Y, Ku Y, Sun J, Daskalakis ZJ *, Yuan TF * (2023) Intermittent theta burst stimulation to the left dorsolateral prefrontal cortex improves working memory of subjects with methamphetamine use disorder.Psychol Med 53: 2427-2436.
11. Han S #, Li XX #, Wei S, Zhao D, Ding J, Xu Y, Yu C, Chen Z, Zhou DS*, Yuan TF * (2023) Orbitofrontal cortex-hippocampus potentiation mediates relief for depression: A randomized double-blind trial and TMS-EEG study. Cell Rep Med 4: 101060.
12. Lv X, Zhang J, Yuan TF * (2022) Retrieval-extinction of drug memory requires AMPA receptor trafficking. Sci Adv 8(51):eadd6642.
13. Xue J, Qian D, Zhang B, Li W, Bao Y, Yang J, Qiu S, Fu Y, Wang S, Yuan TF *, Lu W* (2022) Midbrain dopamine neurons arbiter OCD-like behavior. PNAS 119(46): e2207545119.
14. Zhang K, Guo YC, Wang XD, Zhu YJ, Pan BX, Deng C*, Yuan TF* (2022) Lateral septum inputs to nucleus accumbens mediates stress induced suppression of natural reward seeking. Pharmacol Res 184:106463.
15. Su LY #, Li Y #, Liu Q, Jiao L, Shen J, Yang LX, Yuan TF *, Yao YG * (2022) Decreased peripheral mtDNA in methamphetamine use disorder. Sci China Life Sci 65: 648-650.
16. Wang YJ, Li X, Ng CH, Xu DW *, Hu S *, Yuan TF * (2022) Risk factors for non-suicidal self-injury (NSSI) in adolescents: A meta-analysis. EClinicalMedicine 46: 101350.
17. Zhang H #, Li J #, Su X, Hu Y, Liu T, Ni S, Li H, Zuo XN, Fu J *, Yuan TF *, Yang Z * (2022) Growth charts of brain morphometry for preschool children. Neuroimage 14:119178.
18. Zhou D #, Li A #, Li X #, Zhuang W #, Liang Y, Zheng CY, Zheng H, Yuan TF * (2022) The effects of 40 Hz transcranial alternating current stimulation (tACS) on cognitive functions of patients with Alzheimer's disease: a randomized, double-blind, sham-controlled clinical trial. J Neurol Neurosur Psychiatry 93(5):568-570.
19. Rao Y *, Du S, Du X, Wang Y, Yang B, Li R, Zhou T, He Y, Wang Y, Li Y, Zhou X, Yuan TF *, Mao Y*, Peng B* (2021) Ectopic expression of NeuroD1 is not able to induce the microglia-to-neuron cross-lineage conversion. Neuron 109(24):4094-4108.e5.
20. Zhang Y #, Ren L #, Liu K, Tong S, Yuan TF *, Sun J * (2021) Transcranial ultrasound stimulation of the human motor cortex. iScience 24(12):103429.
21. Cheng T, Huang XD, Hu XF, Wang SQ, Chen K, Wei JA, Yan L, So KF, Yuan TF *, Zhang L *. (2021) Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex. Mol Psychiatry 26: 6187-6197.
22. Zhao D, Zhang M, Tian W, Cao X, Yin L, Liu Y, Xu TL, Luo W*, Yuan TF*. (2021) Neurophysiological correlate of incubation of craving in individuals with methamphetamine use disorder. Mol Psychiatry 26: 6198-6208.
23. Chia CH #, Tang XW #, Cao Y #, Cao HT, Zhang W, Wu JF, Zhu YL, Chen Y, Lin Y, Wu Y, Zhang Z *, Yuan TF *, Hu RP * (2021) Cortical excitability signatures for the degree of sleepiness in human. Elife 10:e65099.
24. Li X #, Qi G #, Yu C #, Lian G, Zheng H, Wu S *, Yuan TF *, Zhou D * (2021) Cortical plasticity is correlated with cognitive improvement in Alzheimer's disease patients after rTMS treatment. Brain Stimul 14(3):503-510.
25. Peng SY #, Shi Z #, Zhou DS #, Wang XY, Li XX, Liu XL, Wang WD, Lin GN, Pan BX, Voon V, Grace AA, Heilig M, Wong ML, Yuan TF * (2021) Reduced motor cortex GABABR function following chronic alcohol exposure. Mol Psychiatry 26: 383-395.
26. Liu X #, Zhao X #, Liu T, Liu Q, Tang L, Zhang H, Luo W *, Daskalakis ZJ, Yuan TF * (2020) The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder. EBioMedicine 56:102809.
27. Liu X #, Zhao X #, Shen Y #, Liu T, Liu Q, Tang L, Zhang H, Luo W *, Yuan TF * (2020) The effects of DLPFC-targeted repetitive transcranial magnetic stimulation on craving in male methamphetamine patients. Clin Transl Med 10(2):e48.
28. Yuan J *, Liu W, Liang Q, Cao X, Lucas MV, Yuan TF* (2020) Effect of low-frequency repetitive transcranial magnetic stimulation on impulse inhibition in abstinent patients with methamphetamine addiction: a randomized clinical trial. JAMA Netw Open 3(3):e200910
29. Zhang M #, Zhao D #, Zhang Z, Cao X, Yin L, Liu Y, Yuan TF *, Luo W * (2019) Time perception deficits and its dose-dependent effect in methamphetamine dependents with short-term abstinence. Science Advances 5: eaax6916.
30. Liang Y, Wang L, Yuan TF * (2018) Targeting Withdrawal Symptoms in Men Addicted to Methamphetamine With Transcranial Magnetic Stimulation: A Randomized Clinical Trial. JAMA Psychiatry 75: 1199-1201.
31. Huang Y #, Xu Z #, Xiong S, Sun F, Qin G, Hu G, Wang J, Zhao L, Liang YX, Wu T, Lu Z, Humayun MS, So KF, Pan Y, Li N, Yuan TF *, Rao Y *, Peng B * (2018) Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. Nat Neurosci. 21: 530-40.
32. Huang X #, Chen YY #, Shen Y #, Cao X #, Li A #, Liu Q #, Li Z, Zhang LB, Dai W, Tan T, Arias-Carrion O*, Xue YX*, Su H*, Yuan TF * (2017) Methamphetamine abuse impairs motor cortical plasticity and function. Mol Psychiatry, 22: 1274-1281
33. Shen Y #, Cao X #, Shan C #, Dai W #, Yuan TF *. (2017) Heroin Addiction Impairs Human Cortical Plasticity. Biol Psychiatry; 81(7):e49-e50.
34. Shen Y #, Cao X #, Tan T #, Shan C #, Wang Y, Pan J, He H, Yuan TF *. (2016) 10 Hz repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex reduces Heroin cue craving in long-term addicts. Biol Psychiatry 80:e13-e14.