职称: 副教授

职务：无

院系：针灸研究院

研究方向：中药药理学、系统药理学等

主要研究方向介绍：[建议控制在500字以内]

研究方向聚焦于基于定量系统药理学与多尺度电生理技术的中药抗心律失常有效组分群发现与机制解析。针对中药复方“多组分-多靶点”协同作用中量效关系不清的核心难题，您以临床验方心速宁胶囊和活心丸为研究对象，致力于揭示其治疗心房颤动、室性早搏、缺血再灌注损伤及心力衰竭的科学内涵。研究采用“计算预测+实验验证”的闭环策略：一方面利用自建的复方组分定量协同算法（CM-QSP）、分子动力学模拟及心肌动作电位仿真模型，从海量组合中精准筛选最优组分配伍；另一方面结合高通量膜片钳、iPSC诱导分化心肌细胞、人工心肌组织、离体心脏灌流及在体动物模型，在离子通道、细胞、组织、器官及整体多个尺度上验证药效。核心目标是阐明中药多组分通过协同调控心脏多离子通道平衡、氧化应激、线粒体功能及钙稳态等网络机制，从而安全有效治疗心律失常的分子机理；并据此挖掘出化学组成明确、比例固定、疗效优于原复方的“有效组分群”（即现代复方化学药）。该研究旨在打破传统中药“黑箱”，构建中药复方现代化研究新范式，推动心血管中药从“经验用药”向“精准设计”转化，为抗心律失常创新药物研发提供坚实的理论基础与技术支撑。

主要学习和工作经历：按时间倒序排列

目前担任的学术职务：

中国中医药信息学会数智医疗分会常务理事

中国中药协会心血管病药物研究专业委员会委员

中国针灸学会数智针灸专业委员会委员

中西医结合学会青委会证书

中国药理学会网络药理学专业委员会青年委员

科研项目：按时间倒序排列

主要论文：按时间倒序排列

[1] Ma Jia Le, Zhang Xin Yuan, Wang Yu Yao, Leng Meng Tong, Li Hui Zhen, Wang Tai Yi. Mechanistic insights into Banxia Xiexin Decotion-induced gastric mucosal restoration in rats with chronic atrophic gastritis and gastric precancerous lesions: the role of the Notch pathway[J/OL]. Traditional Medicine Research, 2026, 11(4): 24.

[2] Lai Jingjiang, Lan Tian, Wang Taiyi, Wang Dawei, Yu Meng, Su Yuxin, Song Guangyu, Tseng Yiider. Metabolomics and network pharmacology revealing the transdermal moxibustion compounds and their therapeutic mechanisms for rheumatoid arthritis[J/OL]. Phytomedicine, 2025, 148: 157479.

[3] Fan Mengyue, Yao Lin, Zhang Guoqing, Wang Ruixue, Chen Kexin, Fan Yujing, Wang Ziming, Fu Jia, Chen Yongjun, Wang Taiyi. Study on subtyping and Traditional Chinese Medicine treatment of depression based on machine learning and text mining[J/OL]. Journal of Traditional Chinese Medicine, 2025, 45(5): 1152.

[4] Huang Mimi, Wang Lingli, Xu Zejun, Huang Chenxing, He Sisi, Liao Yiqiu, Li Jiaxuan, Qin Fei, Chen Yongjun, Zhang Qiqi, Yang Hongjun, Liu Dongyan, Wang Taiyi. Huoxin Pill Ameliorates Atrial Fibrillation by Modulating Autonomic Nervous Balance and Electrical Conduction Heterogeneity: Insights From Systems Pharmacology and Experimental Validation[J/OL]. Basic & Clinical Pharmacology & Toxicology, 2025, 137(2): e70079.

[5] Yang Xiaoyun, Wang Jiaxin, Zhang Jiahao, Zhang Mengjie, Hao Anran, Guo Feng, Huang Xueying, Yan Jinlan, Zheng Yuanjia, Xia Yucen, Wang Taiyi, Zhang Meng, Weng Ning, Chen Yongjun, Yao Lin. Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression[J/OL]. Cell and Bioscience, 2025, 15(1): 97.

[6] Liu Jimin, Tian Xiaqing, Zhang Meng, Li Jiaxuan, Chen Yongjun, Wang Taiyi. Advances in pharmacological research on myocardial remodeling agents: A decade in review[J/OL]. Medicine, 2025, 104(23): e42757.

[7] Liu Jimin, Zai Xiang, Tian Xiaqing, Li Jiaxuan, Yan Shipeng, Wang Taiyi. Practical implementation and impact of the 4R principles in ethnopharmacology: Pursuing a more humane approach to research[J/OL]. Frontiers in Pharmacology, 2025, 16: 1543316.

[8] Xie Weiwei, Gao Jiaming, Liang Yingran, Huang Chenxing, Zhang Boyong, Chen Xiaonan, Yao Xi, Nan Guo, Wu Honghua, Wang Yuefei, Wu Lin, Wang Taiyi, Zhu Yan. Identification of Lauric Acid as a Potent Sodium Channel Na_V1.5 Blocker from Compound Chinese Medicine Wenxin Keli[J/OL]. Drug Design Development and Therapy, 2025, 19: 141-157.

[9] Fan Mengyue, Jin Ching, Li Daping, Deng Yingshan, Yao Lin, Chen Yongjun, Ma Yu Ling, Wang Taiyi. Multi-level advances in databases related to systems pharmacology in traditional Chinese medicine: a 60-year review[J/OL]. Frontiers in Pharmacology, 2023, 14: 1289901.

[10] Wang Jingya, Zhang Qiumei, Yao Lin, He Teng, Chen Xinyi, Su Yang, Sun Shengxuan, Fan Mengyue, Yan Jinglan, Wang Taiyi, Zhang Meng, Guo Feng, Mo Shiqing, Lu Manqi, Zou Meixia, Li Liangjie, Yuan Qing, Pan Huashan, Chen Yongjun. Modulating activity of PVN neurons prevents atrial fibrillation induced circulation dysfunction by electroacupuncture at BL15[J/OL]. Chinese Medicine, 2023, 18(1): 135.

[11] Huang Jing, Yan Jinglan, Wang Taiyi, Chen Yongjun. Research progress on central autonomic nervous mechanism of acupuncture at Neiguan point in the treatment of atrial fibrillation[J/OL]. Acupuncture and Herbal Medicine, 2023, 3(3): 149-157.

[12] Cui Xinyu, Wang Taiyi. Exploring the mechanism of acupuncture for Parkinson’s disease based on network pharmacology techniques[J/OL]. Highlights in Science, Engineering and Technology, 2023, 45: 361-369.

[13] Zheng Yuanjia, Pan Lingyun, Wang Feixue, Yan Jinglan, Wang Taiyi, Xia Yucen, Yao Lin, Deng Kelin, Zheng Yuqi, Xia Xiaoye, Su Zhikai, Chen Hongjie, Lin Jie, Ding Zhenwei, Zhang Kaitong, Zhang Meng, Chen Yongjun. Neural function of Bmal1: an overview[J/OL]. Cell & Bioscience, 2023, 13(1): 1.

[14] Su Yang, Huang Jing, Sun Shengxuan, He Teng, Wang Taiyi, Fan Mengyue, Yu Huanhuan, Yan Jinglan, Yao Lin, Xia Yucen, Zhang Meng, Zheng Yuanjia, Luo Xiaoyan, Zhang Yuewen, Lu Manqi, Zou Meixia, Liu Cunzhi, Chen Yongjun. Restoring the Autonomic Balance in an Atrial Fibrillation Rat Model by Electroacupuncture at the Neiguan Point[J/OL]. Neuromodulation: Technology at the Neural Interface, 2022, 27(7): 1196-1207.

[15] Tao Qianqian, Xiao Guangxu, Wang Taiyi, Zhang Lei, Yu Mingxing, Peng Li, Han Linhong, Du Xiaoli, Han Wenrun, He Shuang, Lyu Ming, Zhu Yan. Identification of linoleic acid as an antithrombotic component of Wenxin Keli via selective inhibition of p-selectin-mediated platelet activation[J/OL]. Biomedicine & Pharmacotherapy, 2022, 153: 113453.

[16] Wang Xuan, Wang Taiyi, Ding Shuwen, Ma Yu Ling. Xin Su Ning—A Review of Basic and Clinical Pharmacology Integrated With Traditional Chinese Medicine Antiarrhythmic Theory[J/OL]. Frontiers in Pharmacology, 2021, 12: 657484.

[17] Lyu Ming, Fan Guanwei, Xiao Guangxu, Wang Taiyi, Xu Dong, Gao Jie, Ge Shaoqin, Li Qingling, Ma Yuling, Zhang Han, Wang Jigang, Cui Yuanlu, Zhang Junhua, Zhu Yan, Zhang Boli. Traditional Chinese medicine in COVID-19[J/OL]. Acta Pharmaceutica Sinica B, 2021, 11(11): 3337-3363.

[18] Jiang Xiumin, Luo Yongxin, Wang Xiaotong, Chen Yiming, Wang Taiyi, He Jun, Xia Yucen, Zhao Jiaying, Chai Xiaoshu, Yao Lin, Liu Cunzhi, Chen Yongjun. Investigating the efficiency and tolerability of traditional Chinese formulas combined with antiarrhythmic agents for paroxysmal atrial fibrillation: A systematic review and Bayesian network meta-analysis[J/OL]. Phytomedicine, 2021, 94(2022): 153832.

[19] Jiang Xiumin, Luo Yongxin, Chen Yiwen, Yan Jinglan, Xia Yucen, Yao Lin, Wang Xiaotong, He Su, Wang Feixue, Wang Taiyi, Chen Yongjun. Comparative Efficacy of Multiple Therapies for the Treatment of Patients With Subthreshold Depression: A Systematic Review and Network Meta-Analysis[J/OL]. Frontiers in Behavioral Neuroscience, 2021, 15: 755547.

[20] Chen Changbao, Shao Rui, Li Bin, Zhai Yu, Wang Taiyi, Li Xin, Miao Lin, Huang Juyang, Liu Rui, Liu Erwei, Zhu Yan, Gao Xiumei, Zhang Han, Wang Yu. Neoisoliquiritin exerts tumor suppressive effects on prostate cancer by repressing androgen receptor activity[J/OL]. Phytomedicine, 2021, 85(2021): 153514.

[21] Xian Fuyang, Liu Tiegang, Bai Chen, Yang Guannan, Ma Xueyan, Wang Bochuan, Huang Ling, Liu Shaoyang, Zhen Jianhua, He Jianzhen, Yu He, Ma Yuling, Wang Taiyi, Gu Xiaohong. Effect of Yinlai Decoction on the metabolic pathways in the lung of high-calorie diet-induced pneumonia rats[J/OL]. Journal of Traditional Chinese Medical Sciences, 2021, 8(1): 4-16.

[22] Ma Yu ling, Hu Rou Mu, Yang Xinchun, Wang Taiyi, Noble Penelope J, Wilkins Robert, Ellory Clive, Carr Carolyn, Noble Denis, Yang Jiefu, Lu Weixing, Zhang Junhua, Hu Hongde, Guo Xiaomei, Chen Min, Wu Yang, Wei Meng, Mao Jingyuan, Ma Xiaochang, Qin Ling, Wu Huanlin, Lu Feng, Cao Ying, Gao Sheng, Gu Wanli. Investigation of the Cellular Pharmacological Mechanism and Clinical Evidence of the Multi-Herbal Antiarrhythmic Chinese Medicine Xin Su Ning[J/OL]. Frontiers in Pharmacology, 2020, 11: 600.

[23] Huang Yu Xi, Xu Ding Qiao, Yue Shi Jun, Chen Yan Yan, Tao Hui Juan, Fu Rui jia, Xing Li Ming, Wang Taiyi, Ma Yu ling, Wang Bao An, Tang Yu Ping, Duan Jin Ao. Deciphering the Active Compounds and Mechanisms of Qixuehe Capsule on Qi Stagnation and Blood Stasis Syndrome: A Network Pharmacology Study[J/OL]. Evidence-Based Complementary and Alternative Medicine, 2020, 2020(1): 5053914.

[24] Mujahid Minahil, Wang Taiyi, Ellory Clive, Wilkins Robert, Ma Yu Ling. The effect of isoliquiritigenin on the hERG potassium channel[J]. British Journal of Pharmacology, 2020, 177(11).

[25] Gao Jiaming, Wang Taiyi, Yao Xi, Xie Weiwei, Shi Xianru, He Shuang, Zhao Tao, Wang Chunhua, Zhu Yan. Clinical evidence-guided network pharmacology analysis reveals a critical contribution of β1-adrenoreceptor upregulation to bradycardia alleviation by Shenxian-Shengmai[J/OL]. BMC Complementary and Alternative Medicine, 2019, 19(1): 357.

[26] Wang Taiyi, Streeter Hamish, Wang Xuan, Purnama Ujang, Lyu Ming, Carr Carolyn, Ma Yu ling. A Network Pharmacology Study of the Multi-Targeting Profile of an Antiarrhythmic Chinese Medicine Xin Su Ning[J/OL]. Frontiers in Pharmacology, 2019, 10: 1138.

[27] Wang Taiyi, Xie Weiwei, Yu Jiahui, Ellory Clive, Wilkins Robert, Zhu Yan, Ma Yu ling. Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning[J/OL]. Frontiers in Pharmacology, 2019, 10: 70.

[28] Liu Haixin, He Shuang, Wang Taiyi, Orang-Ojong Barnabas, Lu Qing, Zhang Zhongqun, Pan Lanlan, Chai Xin, Wu Honghua, Fan Guanwei, Zhang Peng, Feng Yuxin, Song Yun Seon, Gao Xuimei, Karas Richard H, Zhu Yan. Selected Phytoestrogens Distinguish Roles of ERα Transactivation and Ligand Binding for Anti-Inflammatory Activity[J/OL]. Endocrinology, 2018, 159(9): 3351-3364.

[29] Wang Taiyi, Chen Xiaonan, Yu Jiahui, Du Qunqun, Zhu Jie, Yang Mingzhu, Wu Honghua, Wang Meng, Zhu Yan. High-Throughput Electrophysiology Screen Revealed Cardiotoxicity of Strychnine by Selectively Targeting hERG Channel[J/OL]. The American Journal of Chinese Medicine, 2018, 46(08): 1825-1840.

[30] Lyu Ming, Yan Chun Lin, Liu Hai Xin, Wang Tai Yi, Shi Xin Hui, Liu Jin Ping, Orgah John, Fan Guan Wei, Han Ji Hong, Wang Xiao Ying. Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection[J]. Scientific Reports, 2017, 7: 1-18.

[31] Wei Jing, Chen Jing Rui, Pais Eva Maria Arriero, Wang Tai Yi, Miao Lin, Li Lan, Li Ling Yan, Qiu Feng, Hu Li Min, Gao Xiu Mei, Fan Guan Wei. Oxyresveratrol Is a Phytoestrogen Exerting Anti-inflammatory Effects Through NF-κB and Estrogen Receptor Signaling[J/OL]. Inflammation, 2017, 40(4): 1285-1296.

[32] Wang Taiyi, Lu Ming, Du Qunqun, Yao Xi, Zhang Peng, Chen Xiaonan, Xie Weiwei, Li Zheng, Ma Yuling, Zhu Yan. An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis[J/OL]. Molecular BioSystems, 2017, 13(5): 1018-1030.

[33] Tian Xiaoxuan, Chang Lianying, Ma Guangyin, Wang Taiyi, Lv Ming, Wang Zhilong, Chen Liping, Wang Yuefei, Gao Xiumei, Zhu Yan. Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C[J/OL]. Biological & Pharmaceutical Bulletin, 2016, 39(2): 181-191.

[34] Li Ningning, Xu Yintong, Xia Qiang, Bai Cuigai, Wang Taiyi, Wang Lei, He Dingdi, Xie Nannan, Li Lixin, Wang Jing, Zhou Hong Gang, Xu Feng, Yang Cheng, Zhang Quan, Yin Zheng, Guo Yu, Chen Yue. Simplified captopril analogues as NDM-1 inhibitors[J/OL]. Bioorganic & Medicinal Chemistry Letters, 2014, 24(1): 386-389.

[35] 朱欢喜, 于成, 李雪君, 王瑞雪, 陈永君, 王泰一, 邬文晴, 姚琳. 无监督聚类结合隐结构双重分析抑郁症症候分型及用药规律[J]. 四川大学学报（医学版）, 2025, 56(3): 656-664.

[36] 于欢欢, 黄晨星, 张健勇, 李大平, 崔海明, Yu-ling Ma, 王泰一. 从心速宁胶囊的药理学研究进展探讨心律失常中药新药的研发未来[J/OL]. 天津中医药, 2024, 41(12): 1614-1619.

[37] 王泰一, 靳擎, 范梦月, 管飞诗, 李大平, 陈永君. GPT还是GLM?大模型应用于中医药现代化的机遇与挑战[J]. 中国药理学与毒理学杂志, 2023, 37(S1): 5-9.

[38] 范梦月, 迟程, 张家豪, 王瑞雪, 孔庆悦, 王泰一, 颜靖岚, 陈永君. 基于数据挖掘技术探析郁病针刺治疗的腧穴配伍规律[J/OL]. 中国针灸, 2022, 43(3): 269-276+288.

[39] 王飞雪, 颜靖岚, 王泰一, 夏宇岑, 张猛, 姚琳, 陈永君. 多学科交叉创新背景下的针灸转化医学现状和前景[J/OL]. 中国针灸, 2022, 42(12): 1335-1338.

[40] 迟慧彦, 毛超一, 王泰一, 马玉玲, 黄尧洲, 姚春海, 陈少君, 田凤艳, 郎娜. 龙牡加味汤治疗中重度特应性皮炎风湿蕴热证31例临床观察[J/OL]. 中医杂志, 2021(18 vo 62): 1617-1621.

[41] 于巧红, 郭晓, 王萌, 王泰一, 任晓亮. 17种市售中成药中马兜铃酸A的生物药剂学分类研究[J]. 中成药, 2020, 42(06): 1596-1599.

[42] 石羡茹, 王泰一, 高佳明, 马玉玲, 李菊, 朱彦. 从脑心轴解析多靶点抗心律失常中西药物的治疗前景[J/OL]. Journal of Tianjin University of Traditional Chinese Medicine, 2019, 38(5): 506-511.

[43] 邢雪, 郭晓, 任晓亮, 周立伟, 王泰一, 刘虹, 王萌. 杠柳毒苷、杠柳次苷及杠柳苷元生物药剂学分类研究[J]. 中草药, 2019, 50(05): 1082-1087.

[44] 解微微, 高佳明, 石羡茹, 王泰一, 崔英, 朱彦. 从心律失常与心衰并发症的最新临床进展解析中医治疗“脉结代,心动悸”的科学内涵[J]. 中草药, 2018, 49(22): 5448-5455.

[45] 王泰一, 姚茜, 解微微, 崔英, 朱彦. 从稳心颗粒的药理学研究进展探讨抗心律失常复方药物多靶点协同作用机制和研发未来[J/OL]. 天津中医药, 2017, 34(1): 13-17.

[46] 王泰一, 姚茜, 解微微, 崔英, 朱彦. 阴还是阳: 窦房结起搏机制的中医哲学[J/OL]. 中南药学, 2017, 15(3): 257-263.

[47] 姚茜, 杜群群, 王泰一, 解微微, 崔英, 朱彦. 以HCN4为靶向的参仙升脉口服液治疗窦性心动过缓机制探究[J]. 中南药学, 2017, 15(03): 264-267.

[48] 朱莉, 王泰一, 崔英, 朱彦. 心律调节基因与抗心律失常中药靶标研究进展[J]. 中草药, 2016, 47(1): 165-174.

[49] 谭善阳, 王泰一, 王泰一, 王珲, 徐峰. 基于结构的利用分布式计算的虚拟筛选[J/OL]. 计算机与应用化学, 2015, 32(9): 1025-1030.

[50] 吕明, 王泰一, 田晓轩, 石鑫慧, 樊官伟, 张砚, 朱彦. 网络药理学分析揭示的常用活血化瘀中药抗炎-抗血栓作用[J]. 药学学报, 2015, 50(9): 1135-1141.

获奖荣誉：按时间倒序排列

2025年度山东科学技术进步奖 二等奖 （第3位）

2024年度山东中西医结合科学技术奖 一等奖（第5位）